Oliver Staub

Oliver Staub

Oliver Staub

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University of Lausanne
Department of Pharmacology & Toxicology
Rue du Bugnon 27
1011 Lausanne, Switzerland

T: +41 21 692 5407 
F: + 41 21 692 5355

Olivier Staub received his diploma in Chemistry at the University of Bern, Switzerland (1987), and his PhD degree at the University of Lausanne (1992). He was trained as a postdoc at UCLA and at the Hospital for Sick Children in Toronto, before joining the Department of Pharmacology & Toxicology at the University of Lausanne as an independent researcher in 1997. Currently he holds the position of an Associate Professor. The research of Dr. Staub is focused on understanding how ubiquitylation and phosphorylation pathways control sodium and potassium homeostasis and consequently blood pressure. His major contributions concerns the discovery that the ubiquitin-protein ligase NEDD4-2 binds to and downregulates the epithelial Na channel ENaC, a mechanisms defective in Liddle’s syndrome. Subsequent work showed that this pathway is regulated either by controlling NEDD4-2 expression or by phosphorylation of NEDD4-2 by the aldosterone-induced SGK1 kinase. More recently, he developed tubule specific NEDD4-2 and SGK1 knockout mice, and these models illuminated novel roles for NEDD4-2 in the regulation of the thiazide-sensitive co-transporter, NCC, as well as the K-channels ROMK and BK. The laboratory of Dr. Staub applies multidisciplinary approaches that include state-of-the-art methods including biochemistry, molecular-, cellular and proteomics-systems biology, electrophysiology, combined with modern molecular physiology, taking advantage of sophisticated transgenic mouse models. Dr. Staub has published over 80 peer-reviewed papers and book chapters that were cited more than 6000 times.


University of Lausanne
Department of Biomedical Sciences


  • Renal-Tubular SGK1 is Required to Achieve Blood Pressure Surge and Circadian Rhythm.
    Staub O, Debonneville A, Stifanelli M, Juffre A, Maillard MP, Gumz ML, Al-Qusairi L. Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00211.2023. Epub ahead of print. PMID: 37676758. [Article]

  • Does the early aldosterone-induced SGK1 play a role in early Kaliuresis?
    Al-Qusairi L, Basquin D, Stifanelli M, Welling PA, Staub O. Physiol Rep. 2022 Feb;10(4):e15188. doi: 10.14814/phy2.15188. PMID: 35224872; PMCID: PMC8883148. [Article]

  • Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule
    Wu P, Su XT, Gao ZX, Zhang DD, Duan XP, Xiao Y, Staub O, Wang WH, Lin DH. J Am Soc Nephrol. 2020 Jun;31(6):1226-1242. doi: 10.1681/ASN.2019090923. [Article]

  • Mg22+ restriction downregulates NCC through NEDD4-2 and prevents its activation by hypokalemia
    Ferdaus MZ, Mukherjee A, Nelson JW, Blatt PJ, Miller LN, Terker AS, Staub O, Lin DH, McCormick JA. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F825-F838. doi: 10.1152/ajprenal.00216.2019. Epub 2019 Jul 31. PMID: 31364380 [Article]

  • Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling
    Canonica J, Frateschi S, Boscardin E, Ebering A, Sergi C, Jäger Y, Peyrollaz T, Mérillat AM, Maillard M, Klusonova P, Odermatt A, Koesters R, Debonneville A, Staub O, Verouti SN, Hummler E. Front Physiol. 2019 Aug 14;10:989. doi: 10.3389/fphys.2019.00989. eCollection 2019. PMID: 31474871 [Article]

  • The serine-threonine kinase PIM3 is an aldosterone-regulated protein in the distal nephron
    Spirli A, Cheval L, Debonneville A, Penton D, Ronzaud C, Maillard M, Doucet A, Loffing J, Staub O. Physiol Rep. 2019 Aug;7(15):e14177. doi: 10.14814/phy2.14177. PMID: 31397090 [Article]

  • The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation
    Rosenbaek LL, Rizzo F, Wu Q, Rojas-Vega L, Gamba G, MacAulay N, Staub O, Fenton RA. Sci Rep. 2017 Oct 11;7(1):12981. doi: 10.1038/s41598-017-12819-0. PMID: 29021560 [Article]

  • Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion
    Al-Qusairi L, Basquin D, Roy A, Rajaram RD, Maillard MP, Subramanya AR, Staub O. J Am Soc Nephrol. 2017 Aug;28(8):2431-2442. doi: 10.1681/ASN.2016070732. Epub 2017 Mar 13. PMID: 28289184 [Article]

  • Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC
    Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23. PMID: 27009335 [Article]

  • Ubiquitylation and control of renal Na+ balance and blood pressure
    Ronzaud C, Staub O. Physiology (Bethesda). 2014 Jan;29(1):16-26. doi: 10.1152/physiol.00021.2013. PMID: 24382868 Review. [Article]