Publications

2022

Blood pressure effects of sodium transport along the distal nephron.
Castañeda-Bueno M, Ellison DH. Kidney Int. 2022 Dec;102(6):1247-1258. doi: 10.1016/j.kint.2022.09.009. Epub 2022 Oct 10. PMID: 36228680; PMCID: PMC9754644. [Article]

Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.
Neumann C, Rosenbaek LL, Flygaard RK, Habeck M, Karlsen JL, Wang Y, Lindorff-Larsen K, Gad HH, Hartmann R, Lyons JA, Fenton RA, EMBO J. 2022 Dec 1;41(23):e110169. doi: 10.15252/embj.2021110169. Epub 2022 Oct 14. PMID: 36239040; PMCID: PMC9713717. [Article]

Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.
Murillo-de-Ozores AR, Carbajal-Contreras H, Magaña-Ávila GR, Valdés R, Grajeda-Medina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin DH, Wang WH, Delpire E, Ellison DH, Gamba G, Castañeda-Bueno M. Kidney Int. 2022 Nov;102(5):1030-1041. doi: 10.1016/j.kint.2022.06.027. Epub 2022 Jul 21. PMID: 35870644; PMCID: PMC10411384. [Article]

Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.
Petrillo F, Chernyakov D, Esteva-Font C, Poulsen SB, Edemir B, Fenton RA. FASEB J. 2022 Nov;36(11):e22583. doi: 10.1096/fj.202200856R. PMID: 36197017. [Article]

nhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
Moseng MA, Su CC, Rios K, Cui M, Lyu M, Glaza P, Klenotic PA, Delpire E, Yu EW. Sci Adv. 2022 Oct 28;8(43):eabq0952. doi: 10.1126/sciadv.abq0952. Epub 2022 Oct 28. PMID: 36306358; PMCID: PMC9616490. [Article]

The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter NCC but is not required for a potassium-induced reduction of NCC expression.
Rosenbaek LL, Petrillo F, van Bemmelen MX, Staub O, Murali SK, Fenton RA. Front Physiol. 2022 Sep 7;13:971251. doi: 10.3389/fphys.2022.971251. PMID: 36160843; PMCID: PMC9490057. [Article]

Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter.
Wu A, Wolley MJ, Fenton RA, Stowasser M. Front Endocrinol (Lausanne). 2022 Aug 29;13:981317. doi: 10.3389/fendo.2022.981317. PMID: 36105401; PMCID: PMC9465297. [Article]

n Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter.
Wu A, Wolley MJ, Matthews A, Cowley D, Welling PA, Fenton RA, Stowasser M. Kidney360. 2022 Aug 26;3(11):1909-1923. doi: 10.34067/KID.0003632022. PMID: 36514401; PMCID: PMC9717638. [Article]

Potassium homeostasis: sensors, mediators, and targets.
McDonough AA, Fenton RA Pflugers Arch. 2022 Aug;474(8):853-867. doi: 10.1007/s00424-022-02718-3. Epub 2022 Jun 21. PMID: 35727363; PMCID: PMC10163916. [Article]

NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification. Am J Physiol Renal Physiol.
Xue J, Thomas L, Dominguez Rieg JA, Fenton RA, Rieg T. Am J Physiol Renal Physiol. 2022 Aug 1;323(2):F141-F155. doi: 10.1152/ajprenal.00013.2022. Epub 2022 May 30. PMID: 35635321; PMCID: PMC9306792. [Article]

Urinary extracellular vesicles: does cargo reflect tissue?
van Heugten MH, Hoorn EJ, Fenton RA. Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):464-470. doi: 10.1097/MNH.0000000000000822. Epub 2022 Jul 18. PMID: 35894281. [Article]

COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling.
Cornelius RJ, Nelson JW, Su XT, Yang CL, Ellison DH. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F4-F19. doi: 10.1152/ajprenal.00436.2021. Epub 2022 May 9. PMID: 35532068; PMCID: PMC9236871. [Article]

KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia.
Ferdaus MZ, Terker AS, Koumangoye R, Delpire E. Front Cell Dev Biol. 2022 Jul 7;10:931326. doi: 10.3389/fcell.2022.931326. PMID: 35874803; PMCID: PMC9301082. [Article]

Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone’ in press in Hypertension (AHA)
Yujiro Maeoka¹, Xiao-Tong Su¹, Wen-Hui Wang², Xin-Peng Duan², Avika Sharma¹, Na Li³, Olivier Staub^3 4, James A McCormick¹, David H Ellison^1 4 5

PMID: 35506380
DOI: 10.1161/HYPERTENSIONAHA.122.19159

[Article]

Dissecting the Effects of Aldosterone and Hypokalemia on the Epithelial Na+ Channel and the NaCl Cotransporter.
Kristensen M, Fenton RA, Poulsen SB. Front Physiol. 2022 Apr 26;13:800055. doi: 10.3389/fphys.2022.800055. PMID: 35557966; PMCID: PMC9086401. [Article]

Aldosterone-producing adenoma associated with non-suppressed renin: a case series.
Jansen PM, Stowasser M. J Hum Hypertens 2022;36:376-80. [Article]

Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles.
Wu A, Wolley MJ, Wu Q, Cowley D, Palmfeldt J, Welling PA, Fenton RA, Stowasser M. Kidney360. 2022 Mar 1;3(5):910-921. doi: 10.34067/KID.0000362022. PMID: 36128481; PMCID: PMC9438418. [Article]

Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice
Maeoka Y, Ferdaus MZ, Cornelius RJ, Sharma A, Su XT, Miller LN, Robertson JA, Gurley SB, Yang CL, Ellison DH, McCormick JA. J Am Soc Nephrol. 2022 Mar;33(3):584-600. doi: 10.1681/ASN.2021081099. Epub 2022 Jan 21.PMID: 35064051 [Article]

Does the early aldosterone-induced SGK1 play a role in early Kaliuresis?
Al-Qusairi L, Basquin D, Stifanelli M, Welling PA, Staub O. Physiol Rep. 2022 Feb;10(4):e15188. doi: 10.14814/phy2.15188. PMID: 35224872; PMCID: PMC8883148. [Article]

Pendrin-null mice develop severe hypokalemia following dietary Na+ and K+ restriction: role of ENaC.
Pham TD, Elengickal AJ, Verlander JW, Al-Qusairi L, Chen C, Abood DC, King SA, Loffing J, Welling PA, Wall SM. Am J Physiol Renal Physiol. 2022 May 1;322(5):F486-F497. doi: 10.1152/ajprenal.00378.2021. Epub 2022 Feb 28. PMID: 35224991; PMCID: PMC8977139. [Article]

Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice.
Zapf AM, Grimm PR, Al-Qusairi L, Delpire E, Welling PA. Front Physiol. 2022 Jan 6;12:787323. doi: 10.3389/fphys.2021.787323. PMID: 35069250; PMCID: PMC8770744. [Article]

2021

Potassium Effects on NCC Are Attenuated during Inhibition of Cullin E3-Ubiquitin Ligases.
Murali SK, Little R, Poulsen SB, Ferdaus MZ, Ellison DH, McCormick JA, Fenton RA Cells. 2021 Dec 29;11(1):95. doi: 10.3390/cells11010095. PMID: 35011657; PMCID: PMC8750104. [Article]

Diagnosis and treatment of primary aldosteronism
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA. Lancet Diab Endocrinol 2021;9:876-92 [Article]

Insights into Salt Handling and Blood Pressure.
Ellison DH, Welling P.N Engl J Med. 2021 Nov 18;385(21):1981-1993. doi: 10.1056/NEJMra2030212.PMID: 34788509 Review. No abstract available. [Article]

Aldosterone and Primary Aldosteronism: Star Performers in Hypertension Research
Stowasser M.Hypertension. 2021 Sep;78(3):747-750. doi: 10.1161/HYPERTENSIONAHA.121.17594. Epub 2021 Aug 11.PMID: 34379432 No abstract available. [Article]

Compensatory post-diuretic renal sodium reabsorption is not a dominant mechanism of diuretic resistance in acute heart failure
Cox ZL, Rao VS, Ivey-Miranda JB, Moreno-Villagomez J, Mahoney D, Ponikowski P, Biegus J, Turner JM, Maulion C, Bellumkonda L, Asher JL, Parise H, Wilson PF, Ellison DH, Wilcox CS, Testani JM.Eur Heart J. 2021 Sep 16:ehab620. doi: 10.1093/eurheartj/ehab620. Online ahead of print.PMID: 34529781 [Article]

Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron
Nesterov V, Bertog M, Canonica J, Hummler E, Coleman R, Welling PA, Korbmacher C.Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F257-F268. doi: 10.1152/ajprenal.00139.2021. Epub 2021 Jul 12.PMID: 34251271 [Article]

Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure
Poulsen SB, Cheng L, Penton D, Kortenoeven MLA, Matchkov VV, Loffing J, Little R, Murali SK, Fenton RA. Kidney Int. 2021 Apr 30:S0085-2538(21)00461-0. doi: 10.1016/j.kint.2021.04.021 [Article]

An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake.
Kortenoeven MLA, Cheng L, Wu Q, Fenton RA. Am J Physiol Renal Physiol. 2021 May 1;320(5):F908-F921. [Article]

Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles.
Blijdorp CJ, Tutakhel OAZ, Hartjes TA, van den Bosch TPP, van Heugten MH, Rigalli JP, Willemsen R, Musterd-Bhaggoe UM, Barros ER, Carles-Fontana R, Carvajal CA, Arntz OJ, van de Loo FAJ, Jenster G, Clahsen-van Groningen MC, Cuevas CA, Severs D, Fenton RA, van Royen ME, Hoenderop JGJ, Bindels RJM, Hoorn EJ. J Am Soc Nephrol. 2021 May 3;32(5):1210-1226. [Article]

Rapid Development of Vasopressin Resistance in Dietary Potassium Deficiency
Lama Al-Qusairi*, P. Richard Grimm*, Ava M. Zapf, and Paul A. Welling. journals.physiology.org/journal/ajprenal at Johns Hopkins Univ Serials Dept Electronic (162.129.250.015) on March 28, 2021. [Article]

SGLT2-inhibitors, hemodynamics, and kidney protection.
Ellison DH. Am J Physiol Renal Physiol. 2021 Mar 22. doi: 10.1152/ajprenal.00092.2021. Online ahead of print. PMID: 33749325 No abstract available. [Article]

Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus.
Petrillo F, Iervolino A, Angrisano T, Jelen S, Costanzo V, D'Acierno M, Cheng L, Wu Q, Guerriero I, Mazzarella MC, De Falco A, D'Angelo F, Ceccarelli M, Caraglia M, Capasso G, Fenton RA, Trepiccione F. J Am Soc Nephrol. 2021 Mar 16:ASN.2020010031. doi: 10.1681/ASN.2020010031 [Article]

Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter.
Mukherjee A, Yang CL, McCormick JA, Martz K, Sharma A, Ellison DH. Am J Physiol Renal Physiol. 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020. Online ahead of print. PMID: 33719576 [Article]

Effect of furosemide on body composition and urinary proteins that mediate tubular sodium and sodium transport-A randomized controlled trial.
Frank Holden M, Oczachowska-Kulik AE, Fenton RA, Bech JN. Physiol Rep. 2021 Jan;8(24):e14653. doi: 10.14814/phy2.14653. [Article]

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X.J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171. [Article]

Epigenetic regulation of arginine vasopressin receptor 2 expression by PAX2 and Pax transcription interacting protein.
Abraham S, Paknikar R, Bhumbra S, Luan D, Venkatareddy M, O'Connor C, Bitzer M, Fenton RA, Hurd T, Garg P, Patel SR. Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F404-F417. [Article]

Genetic deletion of connexin 37 causes polyuria and polydipsia.
Xue J, Thomas L, Dominguez Rieg JA, Fenton RA, Rieg T. PLoS One. 2020 Dec 17;15(12):e0244251. doi: 10.1371/journal.pone.0244251. eCollection 2020. PMID: 33332450 Free PMC article. [Article]

The Cl-/HCO3- exchanger pendrin is downregulated during oral co-administration of exogenous mineralocorticoid and KCl in patients with primary aldosteronism.
Wu A, Wolley MJ, Wu Q, Gordon RD, Fenton RA, Stowasser M. J Hum Hypertens 2021;35:837-48. [Article]

2020

The Cl−/HCO3− exchanger pendrin is downregulated during oral co-administration of exogenous mineralocorticoid and KCl in patients with primary aldosteronism
Aihua Wu, Martin J. Wolley, Qi Wu, Richard D. Gordon, Robert A. Fenton & Michael Stowasser Journal of Human Hypertension (2020) [Article]

Distal convoluted tubule Cl- concentration is modulated via K+ channels and transporters.
Su XT, Klett NJ, Sharma A, Allen CN, Wang WH, Yang CL, Ellison DH. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F534-F540. doi: 10.1152/ajprenal.00284.2020. Epub 2020 Jul 27. PMID: 32715757 [Article]

A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene.
Cornelius RJ, Sharma A, Su XT, Guo JJ, McMahon JA, Ellison DH, McMahon AP, McCormick JA. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F423-F435. doi: 10.1152/ajprenal.00101.2020. Epub 2020 Jul 13. PMID: 32657158 [Article]

Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging.
Ebrahim Tahaei, Richard Coleman, Turgay Saritas, David H. Ellison, and Paul A Welling. AJP Renal. 2020 Sep 14;doi.org/10.1152/ajprenal.00441.2020 Online ahead of print. [Article]

Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule
Wu P, Su XT, Gao ZX, Zhang DD, Duan XP, Xiao Y, Staub O, Wang WH, Lin DH. J Am Soc Nephrol. 2020 Jun;31(6):1226-1242. doi: 10.1681/ASN.2019090923. [Article]

Effects of Ramipril on the Aldosterone/Renin Ratio and the Aldosterone/Angiotensin II Ratio in Patients With Primary Aldosteronism
Guo Z, Poglitsch M, Cowley D, Domenig O, McWhinney BC, Ungerer JPJ, Wolley M, Stowasser M. Hypertension. 2020 Jun 8:HYPERTENSIONAHA12014871. doi: 10.1161/HYPERTENSIONAHA.120.14871. Online ahead of print. PMID: 32507039 [Article]

Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice.
Wu P, Gao ZX, Zhang DD, Duan XP, Terker AS, Lin DH, Ellison DH, Wang WH. J Am Heart Assoc. 2020 Apr 7;9(7):e014996. doi: 10.1161/JAHA.119.014996. Epub 2020 Mar 25. PMID: 32208832 Free PMC article. [Article]

Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons
Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M. EMBO Rep. 2020 Apr 3;21(4):e48880. doi: 10.15252/embr.201948880. Epub 2020 Feb 17. PMID: 32064760 [Article]

Diagnosis of Primary Aldosteronism by Seated Saline Suppression Test-Variability Between Immunoassay and HPLC-MS/M
Thuzar M, Young K, Ahmed AH, Ward G, Wolley M, Guo Z, Gordon RD, McWhinney BC, Ungerer JP, Stowasser M. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgz150. doi: 10.1210/clinem/dgz150. PMID: 31676899 [Article]

Controversies and advances in adrenal venous sampling in the diagnostic workup of primary aldosteronis
Wolley M, Thuzar M, Stowasser M. Best Pract Res Clin Endocrinol Metab. 2020 Feb 22:101400. doi: 10.1016/j.beem.2020.101400. Online ahead of print. PMID: 32115358 Review. [Article]

Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R; Conference Participants. Kidney Int. 2020 Jan;97(1):42-61. doi: 10.1016/j.kint.2019.09.018. Epub 2019 Oct 10. [Article]

Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis
Hoorn EJ, Gritter M, Cuevas CA, Fenton RA. Physiol Rev. 2020 Jan 1;100(1):321-356. doi: 10.1152/physrev.00044.2018. PMID: 31793845 Review. [Article]

2019

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
Perry JSA, Morioka S, Medina CB, Iker Etchegaray J, Barron B, Raymond MH, Lucas CD, Onengut-Gumuscu S, Delpire E, Ravichandran KS. Nat Cell Biol. 2019 Dec;21(12):1532-1543. doi: 10.1038/s41556-019-0431-1. Epub 2019 Dec 2. PMID: 31792382  [Article]

WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia
Thomson MN, Cuevas CA, Bewarder TM, Dittmayer C, Miller LN, Si J, Cornelius RJ, Su XT, Yang CL, McCormick JA, Hadchouel J, Ellison DH, Bachmann S, Mutig K. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F216-F228. doi: 10.1152/ajprenal.00232.2019. Epub 2019 Nov 18. PMID: 31736353 [Article]

Cryo-EM structures of the human cation-chloride cotransporter KCC1
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J.Science. 2019 Oct 25;366(6464):505-508. doi: 10.1126/science.aay3129. PMID: 31649201 [Article]

SUMOylation Landscape of Renal Cortical Collecting Duct Cells
Wu Q, Aroankins TS, Cheng L, Fenton RA. J Proteome Res. 2019 Oct 4;18(10):3640-3648. doi: 10.1021/acs.jproteome.9b00306. Epub 2019 Sep 18. PMID: 31502464 [Article]

The single-cell transcriptomic landscape of early human diabetic nephropathy
Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625. doi: 10.1073/pnas.1908706116. Epub 2019 Sep 10. PMID: 31506348 [Article]

Mg2²⁺ restriction downregulates NCC through NEDD4-2 and prevents its activation by hypokalemia
Ferdaus MZ, Mukherjee A, Nelson JW, Blatt PJ, Miller LN, Terker AS, Staub O, Lin DH, McCormick JA. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F825-F838. doi: 10.1152/ajprenal.00216.2019. Epub 2019 Jul 31. PMID: 31364380 [Article]

Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling
Canonica J, Frateschi S, Boscardin E, Ebering A, Sergi C, Jäger Y, Peyrollaz T, Mérillat AM, Maillard M, Klusonova P, Odermatt A, Koesters R, Debonneville A, Staub O, Verouti SN, Hummler E. Front Physiol. 2019 Aug 14;10:989. doi: 10.3389/fphys.2019.00989. eCollection 2019. PMID: 31474871 [Article]

The serine-threonine kinase PIM3 is an aldosterone-regulated protein in the distal nephron
Spirli A, Cheval L, Debonneville A, Penton D, Ronzaud C, Maillard M, Doucet A, Loffing J, Staub O. Physiol Rep. 2019 Aug;7(15):e14177. doi: 10.14814/phy2.14177. PMID: 31397090 [Article]

The interplay of renal potassium and sodium handling in blood pressure regulation: critical role of the WNK-SPAK-NCC pathway
Wu A, Wolley M, Stowasser M. J Hum Hypertens. 2019 Jul;33(7):508-523. doi: 10.1038/s41371-019-0170-6. Epub 2019 Feb 5. PMID: 30723251 [Article]

Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter
Cheng L, Poulsen SB, Wu Q, Esteva-Font C, Olesen ETB, Peng L, Olde B, Leeb-Lundberg LMF, Pisitkun T, Rieg T, Dimke H, Fenton RA. J Am Soc Nephrol. 2019 Aug;30(8):1454-1470. doi: 10.1681/ASN.2018101025. Epub 2019 Jun 28. PMID: 31253651 [Article]

Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter
Penton D, Moser S, Wengi A, Czogalla J, Rosenbaek LL, Rigendinger F, Faresse N, Martins JR, Fenton RA, Loffing-Cueni D, Loffing J. J Am Soc Nephrol. 2019 May;30(5):737-750. doi: 10.1681/ASN.2018050540. Epub 2019 Mar 22. PMID: 30902838 [Article]

Pathogenesis of Familial Hyperaldosteronism Type II: New Concepts Involving Anion Channels
Stowasser M, Wolley M, Wu A, Gordon RD, Schewe J, Stölting G, Scholl UI. Curr Hypertens Rep. 2019 Apr 4;21(4):31. doi: 10.1007/s11906-019-0934-y. PMID: 30949771 Review. [Article]

Salt-sensitive transcriptome of isolated kidney distal tubule cells
Swanson EA, Nelson JW, Jeng S, Erspamer KJ, Yang CL, McWeeney S, Ellison DH. Physiol Genomics. 2019 Apr 1;51(4):125-135. doi: 10.1152/physiolgenomics.00119.2018. Epub 2019 Mar 15. PMID: 30875275 [Article]

A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane
Koumangoye R, Omer S, Delpire E. Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C545-C558. doi: 10.1152/ajpcell.00023.2019. Epub 2019 Mar 13. PMID: 30865516 [Article]

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney
Thomson MN, Schneider W, Mutig K, Ellison DH, Kettritz R, Bachmann S. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F292-F300. doi: 10.1152/ajprenal.00464.2018. Epub 2018 Nov 28. PMID: 30484345  [Article]

Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K±  excretion
Su XT, Ellison DH, Wang WH. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F582-F586. doi: 10.1152/ajprenal.00412.2018. Epub 2019 Jan 9. PMID: 30623727 [Article]

2018

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling.
Saritas T, Puelles VG, Su XT, McCormick JA, Welling PA, Ellison DH. Cell Rep. 2018 Dec 4;25(10):2668-2675.e3. doi: 10.1016/j.celrep.2018.11.021. PMID: 30517856  [Article]

Comparison of Seated With Recumbent Saline Suppression Testing for the Diagnosis of Primary Aldosteronism
Stowasser M, Ahmed AH, Cowley D, Wolley M, Guo Z, McWhinney BC, Ungerer JP, Gordon RD. J Clin Endocrinol Metab. 2018 Nov 1;103(11):4113-4124. doi: 10.1210/jc.2018-01394. PMID: 30239841Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625. doi: 10.1073/pnas.1908706116. Epub 2019 Sep 10. PMID: 31506348 [Article]

Proteomic approaches in kidney disease biomarker discovery
Fenton RA. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1817-F1821. doi: 10.1152/ajprenal.00421.2018. Epub 2018 Sep 19. PMID: 30230371 [Article]

CLCN2 chloride channel mutations in familial hyperaldosteronism type II
Scholl UI, Stölting G, Schewe J, Thiel A, Tan H, Nelson-Williams C, Vichot AA, Jin SC, Loring E, Untiet V, Yoo T, Choi J, Xu S, Wu A, Kirchner M, Mertins P, Rump LC, Onder AM, Gamble C, McKenney D, Lash RW, Jones DP, Chune G, Gagliardi P, Choi M, Gordon R, Stowasser M, Fahlke C, Lifton RP. Nat Genet. 2018 Mar;50(3):349-354. doi: 10.1038/s41588-018-0048-5. Epub 2018 Feb 5. PMID: 29403011 [Article]

Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID. J Am Soc Nephrol. 2018 May;29(5):1411-1425. doi: 10.1681/ASN.2017111163. Epub 2018 Feb 26. PMID: 29483157 [Article]

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism
Omata K, Satoh F, Morimoto R, Ito S, Yamazaki Y, Nakamura Y, Anand SK, Guo Z, Stowasser M, Sasano H, Tomlins SA, Rainey WE. Hypertension. 2018 Oct;72(4):874-880. doi: 10.1161/HYPERTENSIONAHA.118.11086. PMID: 30354720 [Article]

2017

DNPEP is not the only peptidase that produces SPAK fragments in kidney
Koumangoye R, Delpire E. Physiol Rep. 2017 Nov;5(21):e13479. doi: 10.14814/phy2.13479. PMID: 29122955 [Article]

The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation
Rosenbaek LL, Rizzo F, Wu Q, Rojas-Vega L, Gamba G, MacAulay N, Staub O, Fenton RA. Sci Rep. 2017 Oct 11;7(1):12981. doi: 10.1038/s41598-017-12819-0. PMID: 29021560 [Article]

Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules
Grimm PR, Coleman R, Delpire E, Welling PA. J Am Soc Nephrol. 2017 Sep;28(9):2597-2606. doi: 10.1681/ASN.2016090948. Epub 2017 Apr 25. PMID: 28442491 [Article]

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport
Zhang J, Karimy JK, Delpire E, Kahle KT. Expert Opin Ther Targets. 2017 Aug;21(8):795-804. doi: 10.1080/14728222.2017.1351949. Epub 2017 Jul 12. PMID: 28679296  Review. [Article]

NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity
Tutakhel OAZ, Moes AD, Valdez-Flores MA, Kortenoeven MLA, Vrie MVD, Jeleń S, Fenton RA, Zietse R, Hoenderop JGJ, Hoorn EJ, Hilbrands L, Bindels RJM. PLoS One. 2017 Apr 21;12(4):e0176220. doi: 10.1371/journal.pone.0176220. eCollection 2017. PMID: 28430812 [Article]

Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion
Al-Qusairi L, Basquin D, Roy A, Rajaram RD, Maillard MP, Subramanya AR, Staub O. J Am Soc Nephrol. 2017 Aug;28(8):2431-2442. doi: 10.1681/ASN.2016070732. Epub 2017 Mar 13. PMID: 28289184 [Article]

WNK Kinase Signaling in Ion Homeostasis and Human Disease
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007. PMID: 28178566 Review. [Article]

Potassium Sensing by Renal Distal Tubules Requires Kir4.1
Cuevas CA, Su XT, Wang MX, Terker AS, Lin DH, McCormick JA, Yang CL, Ellison DH, Wang WH. J Am Soc Nephrol. 2017 Jun;28(6):1814-1825. doi: 10.1681/ASN.2016090935. Epub 2017 Jan 4. PMID: 28052988  [Article]

2016

Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney
Stowasser M, Gordon RD. Physiol Rev. 2016 Oct;96(4):1327-84. doi: 10.1152/physrev.00026.2015. PMID: 27535640 Review. [Article]

In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance
Wolley MJ, Wu A, Xu S, Gordon RD, Fenton RA, Stowasser M. J Am Soc Nephrol. 2017 Jan;28(1):56-63. doi: 10.1681/ASN.2015111221. Epub 2016 Jul 5. PMID: 27381844 [Article]

A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channel
Li X, Ortega B, Kim B, Welling PA. J Biol Chem. 2016 Jul 15;291(29):14963-72. doi: 10.1074/jbc.M116.729822. Epub 2016 May 23. PMID: 27226616 [Article]

Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC
Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23. PMID: 27009335 [Article]

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis
Terker AS, Zhang C, Erspamer KJ, Gamba G, Yang CL, Ellison DH. Kidney Int. 2016 Jan;89(1):127-34. doi: 10.1038/ki.2015.289. Epub 2016 Jan 4. PMID: 26422504 [Article]

2015

Roles and Regulation of Renal K Channels
Welling PA.Annu Rev Physiol. 2016;78:415-35. doi: 10.1146/annurev-physiol-021115-105423. Epub 2015 Dec 11. PMID: 26654186 Review. [Article]

A Systems Level Analysis of Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells
Cheng L, Wu Q, Kortenoeven MLA, Pisitkun T, Fenton RA. Sci Rep. 2015 Aug 4;5:12829. doi: 10.1038/srep12829. PMID: 26239621 [Article]

Integrated compensatory network is activated in the absence of NCC phosphorylation
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA. J Clin Invest. 2015 May;125(5):2136-50. doi: 10.1172/JCI78558. Epub 2015 Apr 20. PMID: 25893600 [Article]

SPAK-mediated NCC regulation in response to low-K+ diet
Wade JB, Liu J, Coleman R, Grimm PR, Delpire E, Welling PA. Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F923-31. doi: 10.1152/ajprenal.00388.2014. Epub 2015 Jan 28. PMID: 25651563 [Article]

Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride
Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH. Cell Metab. 2015 Jan 6;21(1):39-50. doi: 10.1016/j.cmet.2014.12.006. PMID: 25565204 [Article]

2014

Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage
Markadieu N, Rios K, Spiller BW, McDonald WH, Welling PA, Delpire E. J Biol Chem. 2014 Oct 17;289(42):29273-84. doi: 10.1074/jbc.M114.604009. Epub 2014 Aug 27. PMID: 25164821 [Article]

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH. J Clin Invest. 2014 Nov;124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24. PMID: 25250572 [Article]

Ubiquitylation and control of renal Na+ balance and blood pressure
Ronzaud C, Staub O. Physiology (Bethesda). 2014 Jan;29(1):16-26. doi: 10.1152/physiol.00021.2013. PMID: 24382868 Review. [Article]

2013

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension
Picard N, Trompf K, Yang CL, Miller RL, Carrel M, Loffing-Cueni D, Fenton RA, Ellison DH, Loffing J. J Am Soc Nephrol. 2014 Mar;25(3):511-22. doi: 10.1681/ASN.2012121202. Epub 2013 Nov 14. PMID: 24231659 [Article]

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension
Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O. J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25. PMID: 23348737 [Article]

2011

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway
Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O. J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18. PMID: 21852580 [Article]

Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure
Ma D, Taneja TK, Hagen BM, Kim BY, Ortega B, Lederer WJ, Welling PA. Cell. 2011 Jun 24;145(7):1102-15. doi: 10.1016/j.cell.2011.06.007. PMID: 21703452 [Article]

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