Switch Pathway Biochemistry
Highly regulated interactions between kinases, phosphatases other signaling molecules have been proposed to regulate the switch. We have innovated new approaches to study these interactions in vivo for the first time.
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Kidney Remodeling
Switch activation drives a remarkable structural remodeling process of the distal nephron. New organ clearing techniques and microscopic methods are being combined with genomic and proteomic approaches to identify and characterize the genes and pathways that underlie these processes.
Salt Retaining Hormone
Together with clinical studies in Human subjects, new mouse models have been developed and are being characterized to elucidate how the salt retaining hormone, aldosterone, controls the potassium switch.
Clinical-Translational Studies
The switch hypothesis is being explored in human subjects for the first time, testing how dietary potassium, aldosterone and inherited mutations in the switch pathway genes influence plasma potassium levels, switch activation and blood pressure.
Dr. Stowasser and colleagues discuss “Managing hypertension during the COVID-19 pandemic” in Journal of Human Hypertension
Dr. Stowasser and colleagues discuss “Managing hypertension during the COVID-19 pandemic” in Journal of Human Hypertension; PMID: 32409727
Dr. Stowasser and colleagues’ study “Diagnosis of Primary Aldosteronism by Seated Saline Suppression Test-Variability Between Immunoassay and HPLC-MS/MS” study is published in J Clin Endocrinol Metab.
Dr. Stowasser and colleagues’ study “Diagnosis of Primary Aldosteronism by Seated Saline Suppression Test-Variability Between Immunoassay and HPLC-MS/MS” study is published in J Clin Endocrinol Metab; PMID: 31676899
