Insights into Salt Handling and Blood Pressure.
Ellison DH, Welling P.N Engl J Med. 2021 Nov 18;385(21):1981-1993. doi: 10.1056/NEJMra2030212.PMID: 34788509 Review. No abstract available. [Article]
Aldosterone and Primary Aldosteronism: Star Performers in Hypertension Research
Stowasser M.Hypertension. 2021 Sep;78(3):747-750. doi: 10.1161/HYPERTENSIONAHA.121.17594. Epub 2021 Aug 11.PMID: 34379432 No abstract available. [Article]
Compensatory post-diuretic renal sodium reabsorption is not a dominant mechanism of diuretic resistance in acute heart failure
Cox ZL, Rao VS, Ivey-Miranda JB, Moreno-Villagomez J, Mahoney D, Ponikowski P, Biegus J, Turner JM, Maulion C, Bellumkonda L, Asher JL, Parise H, Wilson PF, Ellison DH, Wilcox CS, Testani JM.Eur Heart J. 2021 Sep 16:ehab620. doi: 10.1093/eurheartj/ehab620. Online ahead of print.PMID: 34529781 [Article]
Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron
Nesterov V, Bertog M, Canonica J, Hummler E, Coleman R, Welling PA, Korbmacher C.Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F257-F268. doi: 10.1152/ajprenal.00139.2021. Epub 2021 Jul 12.PMID: 34251271 [Article]
Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure
Poulsen SB, Cheng L, Penton D, Kortenoeven MLA, Matchkov VV, Loffing J, Little R, Murali SK, Fenton RA. Kidney Int. 2021 Apr 30:S0085-2538(21)00461-0. doi: 10.1016/j.kint.2021.04.021 [Article]
An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake.
Kortenoeven MLA, Cheng L, Wu Q, Fenton RA. Am J Physiol Renal Physiol. 2021 May 1;320(5):F908-F921. [Article]
Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles.
Blijdorp CJ, Tutakhel OAZ, Hartjes TA, van den Bosch TPP, van Heugten MH, Rigalli JP, Willemsen R, Musterd-Bhaggoe UM, Barros ER, Carles-Fontana R, Carvajal CA, Arntz OJ, van de Loo FAJ, Jenster G, Clahsen-van Groningen MC, Cuevas CA, Severs D, Fenton RA, van Royen ME, Hoenderop JGJ, Bindels RJM, Hoorn EJ. J Am Soc Nephrol. 2021 May 3;32(5):1210-1226. [Article]
Rapid Development of Vasopressin Resistance in Dietary Potassium Deficiency
Lama Al-Qusairi*, P. Richard Grimm*, Ava M. Zapf, and Paul A. Welling. journals.physiology.org/journal/ajprenal at Johns Hopkins Univ Serials Dept Electronic (162.129.250.015) on March 28, 2021. [Article]
SGLT2-inhibitors, hemodynamics, and kidney protection.
Ellison DH. Am J Physiol Renal Physiol. 2021 Mar 22. doi: 10.1152/ajprenal.00092.2021. Online ahead of print. PMID: 33749325 No abstract available. [Article]
Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus.
Petrillo F, Iervolino A, Angrisano T, Jelen S, Costanzo V, D'Acierno M, Cheng L, Wu Q, Guerriero I, Mazzarella MC, De Falco A, D'Angelo F, Ceccarelli M, Caraglia M, Capasso G, Fenton RA, Trepiccione F. J Am Soc Nephrol. 2021 Mar 16:ASN.2020010031. doi: 10.1681/ASN.2020010031 [Article]
Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter.
Mukherjee A, Yang CL, McCormick JA, Martz K, Sharma A, Ellison DH. Am J Physiol Renal Physiol. 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020. Online ahead of print. PMID: 33719576 [Article]
Effect of furosemide on body composition and urinary proteins that mediate tubular sodium and sodium transport-A randomized controlled trial.
Frank Holden M, Oczachowska-Kulik AE, Fenton RA, Bech JN. Physiol Rep. 2021 Jan;8(24):e14653. doi: 10.14814/phy2.14653. [Article]
Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X.J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171. [Article]
Epigenetic regulation of arginine vasopressin receptor 2 expression by PAX2 and Pax transcription interacting protein.
Abraham S, Paknikar R, Bhumbra S, Luan D, Venkatareddy M, O'Connor C, Bitzer M, Fenton RA, Hurd T, Garg P, Patel SR. Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F404-F417.   [Article]
Genetic deletion of connexin 37 causes polyuria and polydipsia.
Xue J, Thomas L, Dominguez Rieg JA, Fenton RA, Rieg T. PLoS One. 2020 Dec 17;15(12):e0244251. doi: 10.1371/journal.pone.0244251. eCollection 2020. PMID: 33332450 Free PMC article. [Article]