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Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.
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Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.
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Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.
Petrillo F, Chernyakov D, Esteva-Font C, Poulsen SB, Edemir B, Fenton RA. FASEB J. 2022 Nov;36(11):e22583. doi: 10.1096/fj.202200856R. PMID: 36197017. [Article]
nhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
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The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter NCC but is not required for a potassium-induced reduction of NCC expression.
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Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter.
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n Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter.
Wu A, Wolley MJ, Matthews A, Cowley D, Welling PA, Fenton RA, Stowasser M. Kidney360. 2022 Aug 26;3(11):1909-1923. doi: 10.34067/KID.0003632022. PMID: 36514401; PMCID: PMC9717638. [Article]
Potassium homeostasis: sensors, mediators, and targets.
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Urinary extracellular vesicles: does cargo reflect tissue?
van Heugten MH, Hoorn EJ, Fenton RA. Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):464-470. doi: 10.1097/MNH.0000000000000822. Epub 2022 Jul 18. PMID: 35894281. [Article]
COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling.
Cornelius RJ, Nelson JW, Su XT, Yang CL, Ellison DH. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F4-F19. doi: 10.1152/ajprenal.00436.2021. Epub 2022 May 9. PMID: 35532068; PMCID: PMC9236871. [Article]
KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia.
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Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone’ in press in Hypertension (AHA)
Yujiro Maeoka 1Xiao-Tong Su 1Wen-Hui Wang 2Xin-Peng Duan 2Avika Sharma 1Na Li 3Olivier Staub 3 4James A McCormick 1David H Ellison 1 4 5 [Article]
Dissecting the Effects of Aldosterone and Hypokalemia on the Epithelial Na+ Channel and the NaCl Cotransporter.
Kristensen M, Fenton RA, Poulsen SB. Front Physiol. 2022 Apr 26;13:800055. doi: 10.3389/fphys.2022.800055. PMID: 35557966; PMCID: PMC9086401. [Article]
Aldosterone-producing adenoma associated with non-suppressed renin: a case series.
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Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles.
Wu A, Wolley MJ, Wu Q, Cowley D, Palmfeldt J, Welling PA, Fenton RA, Stowasser M. Kidney360. 2022 Mar 1;3(5):910-921. doi: 10.34067/KID.0000362022. PMID: 36128481; PMCID: PMC9438418. [Article]
Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice
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Does the early aldosterone-induced SGK1 play a role in early Kaliuresis?
Al-Qusairi L, Basquin D, Stifanelli M, Welling PA, Staub O. Physiol Rep. 2022 Feb;10(4):e15188. doi: 10.14814/phy2.15188. PMID: 35224872; PMCID: PMC8883148. [Article]
Pendrin-null mice develop severe hypokalemia following dietary Na+ and K+ restriction: role of ENaC.
Pham TD, Elengickal AJ, Verlander JW, Al-Qusairi L, Chen C, Abood DC, King SA, Loffing J, Welling PA, Wall SM. Am J Physiol Renal Physiol. 2022 May 1;322(5):F486-F497. doi: 10.1152/ajprenal.00378.2021. Epub 2022 Feb 28. PMID: 35224991; PMCID: PMC8977139. [Article]
Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice.
Zapf AM, Grimm PR, Al-Qusairi L, Delpire E, Welling PA. Front Physiol. 2022 Jan 6;12:787323. doi: 10.3389/fphys.2021.787323. PMID: 35069250; PMCID: PMC8770744. [Article]