Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons

Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M. EMBO Rep. 2020 Apr 3;21(4):e48880. doi: 10.15252/embr.201948880. Epub 2020 Feb 17. PMID: 32064760

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

Perry JSA, Morioka S, Medina CB, Iker Etchegaray J, Barron B, Raymond MH, Lucas CD, Onengut-Gumuscu S, Delpire E, Ravichandran KS. Nat Cell Biol. 2019 Dec;21(12):1532-1543. doi: 10.1038/s41556-019-0431-1. Epub 2019 Dec 2. PMID: 31792382 

Cryo-EM structures of the human cation-chloride cotransporter KCC1

Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J.Science. 2019 Oct 25;366(6464):505-508. doi: 10.1126/science.aay3129. PMID: 31649201

A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane

Koumangoye R, Omer S, Delpire E. Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C545-C558. doi: 10.1152/ajpcell.00023.2019. Epub 2019 Mar 13. PMID: 30865516

Mechanism of Hyperkalemia-Induced Metabolic Acidosis

Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID. J Am Soc Nephrol. 2018 May;29(5):1411-1425. doi: 10.1681/ASN.2017111163. Epub 2018 Feb 26. PMID: 29483157

DNPEP is not the only peptidase that produces SPAK fragments in kidney

Koumangoye R, Delpire E. Physiol Rep. 2017 Nov;5(21):e13479. doi: 10.14814/phy2.13479. PMID: 29122955

Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules

Grimm PR, Coleman R, Delpire E, Welling PA. J Am Soc Nephrol. 2017 Sep;28(9):2597-2606. doi: 10.1681/ASN.2016090948. Epub 2017 Apr 25. PMID: 28442491

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

Zhang J, Karimy JK, Delpire E, Kahle KT. Expert Opin Ther Targets. 2017 Aug;21(8):795-804. doi: 10.1080/14728222.2017.1351949. Epub 2017 Jul 12. PMID: 28679296  Review.

WNK Kinase Signaling in Ion Homeostasis and Human Disease

Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007. PMID: 28178566 Review.

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

Piechotta K, Lu J, Delpire E., J Biol Chem. 2002 Dec 27;277(52):50812-9. doi: 10.1074/jbc.M208108200. Epub 2002 Oct 16. PMID: 12386165