Monthly Leducq Network Talk series on Jan/07 “Design of a (Kalikrein-1) CRISPR/Cas9 mouse” by Dr.Eric Delpire, PhD

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Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons

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Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M. EMBO Rep. 2020 Apr 3;21(4):e48880. doi: 10.15252/embr.201948880. Epub 2020 Feb 17. PMID: 32064760

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

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Perry JSA, Morioka S, Medina CB, Iker Etchegaray J, Barron B, Raymond MH, Lucas CD, Onengut-Gumuscu S, Delpire E, Ravichandran KS. Nat Cell Biol. 2019 Dec;21(12):1532-1543. doi: 10.1038/s41556-019-0431-1. Epub 2019 Dec 2. PMID: 31792382 

Cryo-EM structures of the human cation-chloride cotransporter KCC1

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Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J.Science. 2019 Oct 25;366(6464):505-508. doi: 10.1126/science.aay3129. PMID: 31649201

A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane

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Koumangoye R, Omer S, Delpire E. Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C545-C558. doi: 10.1152/ajpcell.00023.2019. Epub 2019 Mar 13. PMID: 30865516

Mechanism of Hyperkalemia-Induced Metabolic Acidosis

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Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID. J Am Soc Nephrol. 2018 May;29(5):1411-1425. doi: 10.1681/ASN.2017111163. Epub 2018 Feb 26. PMID: 29483157

DNPEP is not the only peptidase that produces SPAK fragments in kidney

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Koumangoye R, Delpire E. Physiol Rep. 2017 Nov;5(21):e13479. doi: 10.14814/phy2.13479. PMID: 29122955

Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules

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Grimm PR, Coleman R, Delpire E, Welling PA. J Am Soc Nephrol. 2017 Sep;28(9):2597-2606. doi: 10.1681/ASN.2016090948. Epub 2017 Apr 25. PMID: 28442491

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

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Zhang J, Karimy JK, Delpire E, Kahle KT. Expert Opin Ther Targets. 2017 Aug;21(8):795-804. doi: 10.1080/14728222.2017.1351949. Epub 2017 Jul 12. PMID: 28679296  Review.

WNK Kinase Signaling in Ion Homeostasis and Human Disease

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Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007. PMID: 28178566 Review.