SGLT2-inhibitors, hemodynamics, and kidney protection.

Ellison DH.
Am J Physiol Renal Physiol. 2021 Mar 22. doi: 10.1152/ajprenal.00092.2021. Online ahead of print.
PMID: 33749325 No abstract available.

Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter.

Mukherjee A, Yang CL, McCormick JA, Martz K, Sharma A, Ellison DH.
Am J Physiol Renal Physiol. 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020. Online ahead of print.
PMID: 33719576

Distal convoluted tubule Cl- concentration is modulated via K+ channels and transporters.

Su XT, Klett NJ, Sharma A, Allen CN, Wang WH, Yang CL, Ellison DH.
Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F534-F540. doi: 10.1152/ajprenal.00284.2020. Epub 2020 Jul 27.
PMID: 32715757

A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene.

Cornelius RJ, Sharma A, Su XT, Guo JJ, McMahon JA, Ellison DH, McMahon AP, McCormick JA.
Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F423-F435. doi: 10.1152/ajprenal.00101.2020. Epub 2020 Jul 13.
PMID: 32657158

Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice.

Wu P, Gao ZX, Zhang DD, Duan XP, Terker AS, Lin DH, Ellison DH, Wang WH.
J Am Heart Assoc. 2020 Apr 7;9(7):e014996. doi: 10.1161/JAHA.119.014996. Epub 2020 Mar 25.
PMID: 32208832 Free PMC article.

Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R; Conference Participants. Kidney Int. 2020 Jan;97(1):42-61. doi: 10.1016/j.kint.2019.09.018. Epub 2019 Oct 10.

WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia

Thomson MN, Cuevas CA, Bewarder TM, Dittmayer C, Miller LN, Si J, Cornelius RJ, Su XT, Yang CL, McCormick JA, Hadchouel J, Ellison DH, Bachmann S, Mutig K. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F216-F228. doi: 10.1152/ajprenal.00232.2019. Epub 2019 Nov 18. PMID: 31736353

Salt-sensitive transcriptome of isolated kidney distal tubule cells

Swanson EA, Nelson JW, Jeng S, Erspamer KJ, Yang CL, McWeeney S, Ellison DH. Physiol Genomics. 2019 Apr 1;51(4):125-135. doi: 10.1152/physiolgenomics.00119.2018. Epub 2019 Mar 15. PMID: 30875275

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney

Thomson MN, Schneider W, Mutig K, Ellison DH, Kettritz R, Bachmann S. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F292-F300. doi: 10.1152/ajprenal.00464.2018. Epub 2018 Nov 28. PMID: 30484345 

Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K±  excretion

Su XT, Ellison DH, Wang WH. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F582-F586. doi: 10.1152/ajprenal.00412.2018. Epub 2019 Jan 9. PMID: 30623727