Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R; Conference Participants. Kidney Int. 2020 Jan;97(1):42-61. doi: 10.1016/j.kint.2019.09.018. Epub 2019 Oct 10.

WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia

Thomson MN, Cuevas CA, Bewarder TM, Dittmayer C, Miller LN, Si J, Cornelius RJ, Su XT, Yang CL, McCormick JA, Hadchouel J, Ellison DH, Bachmann S, Mutig K. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F216-F228. doi: 10.1152/ajprenal.00232.2019. Epub 2019 Nov 18. PMID: 31736353

Salt-sensitive transcriptome of isolated kidney distal tubule cells

Swanson EA, Nelson JW, Jeng S, Erspamer KJ, Yang CL, McWeeney S, Ellison DH. Physiol Genomics. 2019 Apr 1;51(4):125-135. doi: 10.1152/physiolgenomics.00119.2018. Epub 2019 Mar 15. PMID: 30875275

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney

Thomson MN, Schneider W, Mutig K, Ellison DH, Kettritz R, Bachmann S. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F292-F300. doi: 10.1152/ajprenal.00464.2018. Epub 2018 Nov 28. PMID: 30484345 

Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K±  excretion

Su XT, Ellison DH, Wang WH. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F582-F586. doi: 10.1152/ajprenal.00412.2018. Epub 2019 Jan 9. PMID: 30623727

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling.

Saritas T, Puelles VG, Su XT, McCormick JA, Welling PA, Ellison DH. Cell Rep. 2018 Dec 4;25(10):2668-2675.e3. doi: 10.1016/j.celrep.2018.11.021. PMID: 30517856 

Potassium Sensing by Renal Distal Tubules Requires Kir4.1

Cuevas CA, Su XT, Wang MX, Terker AS, Lin DH, McCormick JA, Yang CL, Ellison DH, Wang WH. J Am Soc Nephrol. 2017 Jun;28(6):1814-1825. doi: 10.1681/ASN.2016090935. Epub 2017 Jan 4. PMID: 28052988 

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

Terker AS, Zhang C, Erspamer KJ, Gamba G, Yang CL, Ellison DH. Kidney Int. 2016 Jan;89(1):127-34. doi: 10.1038/ki.2015.289. Epub 2016 Jan 4. PMID: 26422504

Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride

Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH. Cell Metab. 2015 Jan 6;21(1):39-50. doi: 10.1016/j.cmet.2014.12.006. PMID: 25565204

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3

McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH. J Clin Invest. 2014 Nov;124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24. PMID: 25250572