SGLT2-inhibitors, hemodynamics, and kidney protection.

/in , /by

Ellison DH.
Am J Physiol Renal Physiol. 2021 Mar 22. doi: 10.1152/ajprenal.00092.2021. Online ahead of print.
PMID: 33749325 No abstract available.

Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter.

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Mukherjee A, Yang CL, McCormick JA, Martz K, Sharma A, Ellison DH.
Am J Physiol Renal Physiol. 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020. Online ahead of print.
PMID: 33719576

Distal convoluted tubule Cl- concentration is modulated via K+ channels and transporters.

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Su XT, Klett NJ, Sharma A, Allen CN, Wang WH, Yang CL, Ellison DH.
Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F534-F540. doi: 10.1152/ajprenal.00284.2020. Epub 2020 Jul 27.
PMID: 32715757

A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene.

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Cornelius RJ, Sharma A, Su XT, Guo JJ, McMahon JA, Ellison DH, McMahon AP, McCormick JA.
Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F423-F435. doi: 10.1152/ajprenal.00101.2020. Epub 2020 Jul 13.
PMID: 32657158

Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice.

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Wu P, Gao ZX, Zhang DD, Duan XP, Terker AS, Lin DH, Ellison DH, Wang WH.
J Am Heart Assoc. 2020 Apr 7;9(7):e014996. doi: 10.1161/JAHA.119.014996. Epub 2020 Mar 25.
PMID: 32208832 Free PMC article.

Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

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Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R; Conference Participants. Kidney Int. 2020 Jan;97(1):42-61. doi: 10.1016/j.kint.2019.09.018. Epub 2019 Oct 10.

WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia

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Thomson MN, Cuevas CA, Bewarder TM, Dittmayer C, Miller LN, Si J, Cornelius RJ, Su XT, Yang CL, McCormick JA, Hadchouel J, Ellison DH, Bachmann S, Mutig K. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F216-F228. doi: 10.1152/ajprenal.00232.2019. Epub 2019 Nov 18. PMID: 31736353

Salt-sensitive transcriptome of isolated kidney distal tubule cells

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Swanson EA, Nelson JW, Jeng S, Erspamer KJ, Yang CL, McWeeney S, Ellison DH. Physiol Genomics. 2019 Apr 1;51(4):125-135. doi: 10.1152/physiolgenomics.00119.2018. Epub 2019 Mar 15. PMID: 30875275

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney

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Thomson MN, Schneider W, Mutig K, Ellison DH, Kettritz R, Bachmann S. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F292-F300. doi: 10.1152/ajprenal.00464.2018. Epub 2018 Nov 28. PMID: 30484345 

Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K±  excretion

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Su XT, Ellison DH, Wang WH. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F582-F586. doi: 10.1152/ajprenal.00412.2018. Epub 2019 Jan 9. PMID: 30623727