Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles.

Wu A, Wolley MJ, Wu Q, Cowley D, Palmfeldt J, Welling PA, Fenton RA, Stowasser M.

Kidney360. 2022 Mar 1;3(5):910-921. doi: 10.34067/KID.0000362022. PMID: 36128481; PMCID: PMC9438418.

Diagnosis and treatment of primary aldosteronism

Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA. Lancet Diab Endocrinol 2021;9:876-92

Aihua Wu from Dr. Stowasser lab gave a talk “Supplementary KCl is associated with decreased abundances of sodium chloride cotransporter (NCC) and phosphorylated NCC (pNCC) in urinary extracellular vesicles (uEVs) of healthy adults maintained on a high-Na+ low-K+ diet”Asian pacific society of hypertension (APCH) annual scientific meeting (virtual), 24-28 Nov, 2021, and was selected for young inverstigator award.

Congratulation to Wu A who got Young Investigator Award, 16th Asian-Pacific Congress of Hypertension Hybrid Meeting (Online), 26-28 November, 2021, New Delhi, India

Aldosterone and Primary Aldosteronism: Star Performers in Hypertension Research

Stowasser M.Hypertension. 2021 Sep;78(3):747-750. doi: 10.1161/HYPERTENSIONAHA.121.17594. Epub 2021 Aug 11.PMID: 34379432 No abstract available.

Aihua Wu from Dr. Stowasser lab gave a talk “Acute kcl replacement decreases the thiazide-sensitive sodium chloride cotransporter (NCC) abundance and phosphorylation in hypertensive patients with raised aldosterone-to-renin ratios (arrs).” in 56th Annual Scientific Meeting of Australia and New Zealand Society of Nephrology (Online), 30 Aug-1 Sept, 2021

Aihua Wu from Dr. Stowasser presented poster “Acute potassium (K+) loading suppresses sodium chloride cotransporter (NCC) abundance in urinary extracellular vesicles (uEVs) in hypertensive patients with raised aldosterone-to-renin ratios (ARRs).” ePoster, In 60th PAH Health Symposium 2021 (Online), 24-27 Aug, 2021

Dr. Stowasser gave a talk “Pendrin reduction is associated with acute intravenous sodium chloride loading in patients with primary aldosteronism.” In Joint Meeting ESH-ISH ON-AIR 2021, 11-14 April,2021

The Cl-/HCO3- exchanger pendrin is downregulated during oral co-administration of exogenous mineralocorticoid and KCl in patients with primary aldosteronism.

Wu A, Wolley MJ, Wu Q, Gordon RD, Fenton RA, Stowasser M.  J Hum Hypertens 2021;35:837-48.

Aihua Wu gave a talk “Thiazide Treatment Effects on NCC Abundance and Phosphorylation in 2 FHHt Patients.” at the 55th Online Annual Scientific Meeting of the Australia and New Zealand Society of Nephrology, 30 November- 2 December, 2020.