Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron

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Viatcheslav Nesterov 1, Marko Bertog 1, Jérémie Canonica 2, Edith Hummler 3, Richard Coleman 4, Paul A Welling 5, Christoph Korbmacher 1

APSselected article for May, 2021, “Low Potassium levels linked to Water Balance Disorder More Prevalent in Women” Study by Al-Quisari, Grimm, Zaph, and Welling .

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https://www.physiology.org/detail/news/2021/05/11/low-potassium-levels-linked-to-water-balance-disorder-more-prevalent-in-women?SSO=Y

Rapid Development of Vasopressin Resistance in Dietary Potassium Deficiency

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Lama Al-Qusairi*, P. Richard Grimm*, Ava M. Zapf, and Paul A. Welling. journals.physiology.org/journal/ajprenal at Johns Hopkins Univ Serials Dept Electronic (162.129.250.015) on March 28, 2021.

Dr. Lama Al-Qusairi awarded her study “Molecular Underpinning of Sexual Dimorphism in Potassium Regulation” from W. Leigh Thompson Excellence in Research: Basic Research Faculty Award

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Molecular Underpinning of Sexual Dimorphism in Potassium Regulation

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.

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Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O’Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X.J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171.

Monthly Leducq Network Talk series on Dec/03/2020 “Potassium and Blood Pressure : Engineering and Phenotyping Mice to test the Switch Hypothesis” by Dr. Paul A. Welling, MD

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Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging.

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Ebrahim Tahaei, Richard Coleman, Turgay Saritas, David H. Ellison, and Paul A Welling. AJP Renal. 2020 Sep 14;doi.org/10.1152/ajprenal.00441.2020 Online ahead of print.

The single-cell transcriptomic landscape of early human diabetic nephropathy

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Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625. doi: 10.1073/pnas.1908706116. Epub 2019 Sep 10. PMID: 31506348

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling.

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Saritas T, Puelles VG, Su XT, McCormick JA, Welling PA, Ellison DH. Cell Rep. 2018 Dec 4;25(10):2668-2675.e3. doi: 10.1016/j.celrep.2018.11.021. PMID: 30517856 

Mechanism of Hyperkalemia-Induced Metabolic Acidosis

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Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID. J Am Soc Nephrol. 2018 May;29(5):1411-1425. doi: 10.1681/ASN.2017111163. Epub 2018 Feb 26. PMID: 29483157