Acute intravenous NaCl and volume expansion reduces sodium-chloride-cotransporter abundance and phosphorylation in urinary extracellular vesicles.

Aihua Wu 1, Martin J Wolley 1 2, Qi Wu 3, Diane Cowley 1, Johan Palmfeldt 4, Paul A Welling 5, Robert A Fenton 3, Michael Stowasser 1

Insights into Salt Handling and Blood Pressure.

Ellison DH, Welling P.N Engl J Med. 2021 Nov 18;385(21):1981-1993. doi: 10.1056/NEJMra2030212.PMID: 34788509 Review. No abstract available.

Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron

Nesterov V, Bertog M, Canonica J, Hummler E, Coleman R, Welling PA, Korbmacher C.Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F257-F268. doi: 10.1152/ajprenal.00139.2021. Epub 2021 Jul 12.PMID: 34251271

APSselected article for May, 2021, “Low Potassium levels linked to Water Balance Disorder More Prevalent in Women” Study by Al-Quisari, Grimm, Zaph, and Welling .

https://www.physiology.org/detail/news/2021/05/11/low-potassium-levels-linked-to-water-balance-disorder-more-prevalent-in-women?SSO=Y

Rapid Development of Vasopressin Resistance in Dietary Potassium Deficiency

Lama Al-Qusairi*, P. Richard Grimm*, Ava M. Zapf, and Paul A. Welling. journals.physiology.org/journal/ajprenal at Johns Hopkins Univ Serials Dept Electronic (162.129.250.015) on March 28, 2021.

Dr. Lama Al-Qusairi awarded her study “Molecular Underpinning of Sexual Dimorphism in Potassium Regulation” from W. Leigh Thompson Excellence in Research: Basic Research Faculty Award

Molecular Underpinning of Sexual Dimorphism in Potassium Regulation

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.

Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O’Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X.J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171.

Monthly Leducq Network Talk series on Dec/03/2020 “Potassium and Blood Pressure : Engineering and Phenotyping Mice to test the Switch Hypothesis” by Dr. Paul A. Welling, MD

Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging.

Ebrahim Tahaei, Richard Coleman, Turgay Saritas, David H. Ellison, and Paul A Welling. AJP Renal. 2020 Sep 14;doi.org/10.1152/ajprenal.00441.2020 Online ahead of print.