David H. EllisonProfessor of Medicine and Chemical Physiology & Biochemistry
Oregon Clinical and Translational Research Institute
Oregon Health and Science University, SN4N
3181 SW Sam Jackson Park Road
Portland, OR 97239, USA
F: +1 503 494 9277
David H. Ellison, M.D. is Professor of Medicine and Physiology & Pharmacology, Director of the Oregon Clinical and Translational Research Institute, and Associate Vice President for Clinical and Translational Research at Oregon Health & Science University. Prior to assuming these roles, he was Head of the Division of Nephrology and Hypertension for 13 years, and he remains active clinically. He is also a Staff Physician at the Portland VA Medical Center. Dr. Ellison’s research focus during the last 25 years has been the mechanisms of salt and potassium transport along the renal distal tubule, with particular interest in the thiazide-sensitive NaCl cotransporter (NCC). His early studies identified this transporter as dominant in the early distal tubule, and his work contributed to the recognition that NCC mutations cause Gitelman syndrome. More recently, he has helped unravel mechanisms underlying the monogenic disease Familial Hyperkalemic Hypertension. This has led him to identify that the distal nephron acts as a potassium switch, through the actions of WNK/SPAK signaling. His work has been instrumental in showing that plasma potassium is a dominant regulator of NCC function, and postulating that this effect results from activation of basolateral potassium channels, leading to cellular polarization and WNK.SPAK activation. His group has translated these findings to humans, and postulated that these mechanisms may explain the blood pressure lowering effects of dietary potassium loading.
- SGLT2-inhibitors, hemodynamics, and kidney protection.
Ellison DH. Am J Physiol Renal Physiol. 2021 Mar 22. doi: 10.1152/ajprenal.00092.2021. Online ahead of print. PMID: 33749325 No abstract available. [Article]
- Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter.
Mukherjee A, Yang CL, McCormick JA, Martz K, Sharma A, Ellison DH. Am J Physiol Renal Physiol. 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020. Online ahead of print. PMID: 33719576 [Article]
- Distal convoluted tubule Cl- concentration is modulated via K+ channels and transporters.
Su XT, Klett NJ, Sharma A, Allen CN, Wang WH, Yang CL, Ellison DH. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F534-F540. doi: 10.1152/ajprenal.00284.2020. Epub 2020 Jul 27. PMID: 32715757 [Article]
- A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene.
Cornelius RJ, Sharma A, Su XT, Guo JJ, McMahon JA, Ellison DH, McMahon AP, McCormick JA. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F423-F435. doi: 10.1152/ajprenal.00101.2020. Epub 2020 Jul 13. PMID: 32657158 [Article]
- Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice.
Wu P, Gao ZX, Zhang DD, Duan XP, Terker AS, Lin DH, Ellison DH, Wang WH. J Am Heart Assoc. 2020 Apr 7;9(7):e014996. doi: 10.1161/JAHA.119.014996. Epub 2020 Mar 25. PMID: 32208832 Free PMC article. [Article]
- Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R; Conference Participants. Kidney Int. 2020 Jan;97(1):42-61. doi: 10.1016/j.kint.2019.09.018. Epub 2019 Oct 10. [Article]
- WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia
Thomson MN, Cuevas CA, Bewarder TM, Dittmayer C, Miller LN, Si J, Cornelius RJ, Su XT, Yang CL, McCormick JA, Hadchouel J, Ellison DH, Bachmann S, Mutig K. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F216-F228. doi: 10.1152/ajprenal.00232.2019. Epub 2019 Nov 18. PMID: 31736353 [Article]
- Salt-sensitive transcriptome of isolated kidney distal tubule cells
Swanson EA, Nelson JW, Jeng S, Erspamer KJ, Yang CL, McWeeney S, Ellison DH. Physiol Genomics. 2019 Apr 1;51(4):125-135. doi: 10.1152/physiolgenomics.00119.2018. Epub 2019 Mar 15. PMID: 30875275 [Article]
- Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney
Thomson MN, Schneider W, Mutig K, Ellison DH, Kettritz R, Bachmann S. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F292-F300. doi: 10.1152/ajprenal.00464.2018. Epub 2018 Nov 28. PMID: 30484345 [Article]
- Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K± excretion
Su XT, Ellison DH, Wang WH. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F582-F586. doi: 10.1152/ajprenal.00412.2018. Epub 2019 Jan 9. PMID: 30623727 [Article]