Eric Delpire, B.H. Robbins Endowed Direcor in Anesthesiology, is Professor of Anesthesiology and Molecular Physiology & Biophysics at Vanderbilt University Medical Center. He received his PhD in Physiology from the University of Liège, Belgium and trained at Wright State University, Dayton, OH and Brigham and Women’s Hospital, Boston, MA. For the past 23 years, he has conducted research in the Department of Anesthesiology, Vanderbilt University Medical Center in Nashville, TN. He is a recognized expert in the fields of cell volume regulation and ion transport in neurons and epithelial cells. He is credited for the discovery of the interaction between SPAK/OSR1 and cation-chloride cotransporters and the interaction between SPAK/OSR1 and WNK kinases. These discoveries led to the characterization of the WNK-SPAK kinase cascade, a regulatory pathway critical in the regulation of salt transport in the distal nephron. Since 1999, Dr. Delpire has created numerous genetically-modified mouse models of cation-chloride transporters, kinases, and other regulatory molecules. These include traditional global and conditional knockout or knockin mice as well CRISPR/cas9-generated knockout and knockin mice. Dr. Delpire has published over 170 peer-reviewed papers and several book chapters. He is a fellow of the American Association for the Advancement of Science and a fellow of the American Physiological Society.

Publications

• Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons
  Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M. EMBO Rep. 2020 Apr 3;21(4):e48880. doi: 10.15252/embr.201948880. Epub 2020 Feb 17. PMID: 32064760 [Article]


• Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
  Perry JSA, Morioka S, Medina CB, Iker Etchegaray J, Barron B, Raymond MH, Lucas CD, Onengut-Gumuscu S, Delpire E, Ravichandran KS. Nat Cell Biol. 2019 Dec;21(12):1532-1543. doi: 10.1038/s41556-019-0431-1. Epub 2019 Dec 2. PMID: 31792382  [Article]


• Cryo-EM structures of the human cation-chloride cotransporter KCC1
  Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J.Science. 2019 Oct 25;366(6464):505-508. doi: 10.1126/science.aay3129. PMID: 31649201 [Article]


• A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane
  Koumangoye R, Omer S, Delpire E. Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C545-C558. doi: 10.1152/ajpcell.00023.2019. Epub 2019 Mar 13. PMID: 30865516 [Article]


• Mechanism of Hyperkalemia-Induced Metabolic Acidosis
  Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID. J Am Soc Nephrol. 2018 May;29(5):1411-1425. doi: 10.1681/ASN.2017111163. Epub 2018 Feb 26. PMID: 29483157 [Article]


• DNPEP is not the only peptidase that produces SPAK fragments in kidney
  Koumangoye R, Delpire E. Physiol Rep. 2017 Nov;5(21):e13479. doi: 10.14814/phy2.13479. PMID: 29122955 [Article]


• Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules
  Grimm PR, Coleman R, Delpire E, Welling PA. J Am Soc Nephrol. 2017 Sep;28(9):2597-2606. doi: 10.1681/ASN.2016090948. Epub 2017 Apr 25. PMID: 28442491 [Article]


• Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport
  Zhang J, Karimy JK, Delpire E, Kahle KT. Expert Opin Ther Targets. 2017 Aug;21(8):795-804. doi: 10.1080/14728222.2017.1351949. Epub 2017 Jul 12. PMID: 28679296  Review. [Article]


• WNK Kinase Signaling in Ion Homeostasis and Human Disease
  Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007. PMID: 28178566 Review. [Article]


• Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)
  Piechotta K, Lu J, Delpire E., J Biol Chem. 2002 Dec 27;277(52):50812-9. doi: 10.1074/jbc.M208108200. Epub 2002 Oct 16. PMID: 12386165 [Article]