Eric Delpire, B.H. Robbins Endowed Direcor in Anesthesiology, is Professor of Anesthesiology and Molecular Physiology & Biophysics at Vanderbilt University Medical Center. He received his PhD in Physiology from the University of Liège, Belgium and trained at Wright State University, Dayton, OH and Brigham and Women’s Hospital, Boston, MA. For the past 23 years, he has conducted research in the Department of Anesthesiology, Vanderbilt University Medical Center in Nashville, TN. He is a recognized expert in the fields of cell volume regulation and ion transport in neurons and epithelial cells. He is credited for the discovery of the interaction between SPAK/OSR1 and cation-chloride cotransporters and the interaction between SPAK/OSR1 and WNK kinases. These discoveries led to the characterization of the WNK-SPAK kinase cascade, a regulatory pathway critical in the regulation of salt transport in the distal nephron. Since 1999, Dr. Delpire has created numerous genetically-modified mouse models of cation-chloride transporters, kinases, and other regulatory molecules. These include traditional global and conditional knockout or knockin mice as well CRISPR/cas9-generated knockout and knockin mice. Dr. Delpire has published over 170 peer-reviewed papers and several book chapters. He is a fellow of the American Association for the Advancement of Science and a fellow of the American Physiological Society.

Publications

• Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl co-transporter and reduces blood pressure.
  Grimm PR, Tatomir A, Rosenbaek LL, Kim BY, Li D, Delpire EJ, Fenton RA, Welling PA

  J Clin Invest. 2023 Sep 7:e158498. doi: 10.1172/JCI158498. Epub ahead of print. PMID: 37676724.

  [Article]


• The K-Cl cotransporter-3 in the mammalian kidney.
  Ferdaus MZ, Delpire E. Curr Opin Nephrol Hypertens. 2023 Sep 1;32(5):482-489. doi: 10.1097/MNH.0000000000000911. Epub 2023 Jun 30. PMID: 37530088; PMCID: PMC10403293. [Article]


• Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect.
  Al-Qusairi L, Ferdaus MZ, Pham TD, Li D, Grimm PR, Zapf AM, Abood DC, Tahaei E, Delpire E, Wall SM, Welling PA Am J Physiol Renal Physiol. 2023 Sep 1;325(3):F377-F393. doi: 10.1152/ajprenal.00193.2023. Epub 2023 Jul 27. PMID: 37498547. [Article]


• Recent Insights into Channelopathies.
  Harraz OF, Delpire E.

  Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00022.2023. Epub ahead of print. PMID: 37561136.

  [Article]


• Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells.
  Ferdaus MZ, Terker AS, Koumangoye R, Wall SM, Delpire E. Am J Physiol Cell Physiol. 2023 May 1;324(5):C1171-C1178. doi: 10.1152/ajpcell.00094.2023. Epub 2023 Apr 10. PMID: 37036298; PMCID: PMC10191129. [Article]


• Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.
  Murillo-de-Ozores AR, Carbajal-Contreras H, Magaña-Ávila GR, Valdés R, Grajeda-Medina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin DH, Wang WH, Delpire E, Ellison DH, Gamba G, Castañeda-Bueno M. Kidney Int. 2022 Nov;102(5):1030-1041. doi: 10.1016/j.kint.2022.06.027. Epub 2022 Jul 21. PMID: 35870644; PMCID: PMC10411384. [Article]


• nhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
  Moseng MA, Su CC, Rios K, Cui M, Lyu M, Glaza P, Klenotic PA, Delpire E, Yu EW. Sci Adv. 2022 Oct 28;8(43):eabq0952. doi: 10.1126/sciadv.abq0952. Epub 2022 Oct 28. PMID: 36306358; PMCID: PMC9616490. [Article]


• KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia.
  Ferdaus MZ, Terker AS, Koumangoye R, Delpire E. Front Cell Dev Biol. 2022 Jul 7;10:931326. doi: 10.3389/fcell.2022.931326. PMID: 35874803; PMCID: PMC9301082. [Article]


• Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice.
  Zapf AM, Grimm PR, Al-Qusairi L, Delpire E, Welling PA. Front Physiol. 2022 Jan 6;12:787323. doi: 10.3389/fphys.2021.787323. PMID: 35069250; PMCID: PMC8770744. [Article]


• Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons
  Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M. EMBO Rep. 2020 Apr 3;21(4):e48880. doi: 10.15252/embr.201948880. Epub 2020 Feb 17. PMID: 32064760 [Article]