Robert A. Fenton received his PhD in Physiology from the University of Manchester, UK and undertook the majority of his postdoctoral training at the Laboratory of Kidney and Electrolyte Metabolism, National Institutes of Health, Bethesda, USA. For the last 15 years he has conducted research at Aarhus University, Denmark, where he is currently Professor of Molecular Cell Biology and leader of a membrane protein research group and research center. He is recognized internationally as a major contributor to the core knowledge base of renal epithelial cell physiology and nephrology and has made landmark achievements in the field of urea transporters, aquaporin water channels and various renal cotransporters. Prof. Fenton’s current research uses a systems biology approach to unravel the role of various renal membrane transport proteins in the control of blood pressure and water balance. He has published over 150 peer-reviewed manuscripts and his scientific accomplishments are recognized by numerous competitive national and international awards from the Renal Section of the American Physiological Society and the Nordic research community, including the Anders Jahre Prize for Young Researchers and the Danish Ministry for Higher Education and Science Elite Research Prize.

Publications

• Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure
  Poulsen SB, Cheng L, Penton D, Kortenoeven MLA, Matchkov VV, Loffing J, Little R, Murali SK, Fenton RA. Kidney Int. 2021 Apr 30:S0085-2538(21)00461-0. doi: 10.1016/j.kint.2021.04.021 [Article]


• An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake.
  Kortenoeven MLA, Cheng L, Wu Q, Fenton RA. Am J Physiol Renal Physiol. 2021 May 1;320(5):F908-F921. [Article]


• Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles.
  Blijdorp CJ, Tutakhel OAZ, Hartjes TA, van den Bosch TPP, van Heugten MH, Rigalli JP, Willemsen R, Musterd-Bhaggoe UM, Barros ER, Carles-Fontana R, Carvajal CA, Arntz OJ, van de Loo FAJ, Jenster G, Clahsen-van Groningen MC, Cuevas CA, Severs D, Fenton RA, van Royen ME, Hoenderop JGJ, Bindels RJM, Hoorn EJ. J Am Soc Nephrol. 2021 May 3;32(5):1210-1226. [Article]


• Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus.
  Petrillo F, Iervolino A, Angrisano T, Jelen S, Costanzo V, D'Acierno M, Cheng L, Wu Q, Guerriero I, Mazzarella MC, De Falco A, D'Angelo F, Ceccarelli M, Caraglia M, Capasso G, Fenton RA, Trepiccione F. J Am Soc Nephrol. 2021 Mar 16:ASN.2020010031. doi: 10.1681/ASN.2020010031 [Article]


• Effect of furosemide on body composition and urinary proteins that mediate tubular sodium and sodium transport-A randomized controlled trial.
  Frank Holden M, Oczachowska-Kulik AE, Fenton RA, Bech JN. Physiol Rep. 2021 Jan;8(24):e14653. doi: 10.14814/phy2.14653. [Article]


• Epigenetic regulation of arginine vasopressin receptor 2 expression by PAX2 and Pax transcription interacting protein.
  Abraham S, Paknikar R, Bhumbra S, Luan D, Venkatareddy M, O'Connor C, Bitzer M, Fenton RA, Hurd T, Garg P, Patel SR. Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F404-F417.   [Article]


• Genetic deletion of connexin 37 causes polyuria and polydipsia.
  Xue J, Thomas L, Dominguez Rieg JA, Fenton RA, Rieg T. PLoS One. 2020 Dec 17;15(12):e0244251. doi: 10.1371/journal.pone.0244251. eCollection 2020. PMID: 33332450 Free PMC article. [Article]


• Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis
  Hoorn EJ, Gritter M, Cuevas CA, Fenton RA. Physiol Rev. 2020 Jan 1;100(1):321-356. doi: 10.1152/physrev.00044.2018. PMID: 31793845 Review. [Article]


• SUMOylation Landscape of Renal Cortical Collecting Duct Cells
  Wu Q, Aroankins TS, Cheng L, Fenton RA. J Proteome Res. 2019 Oct 4;18(10):3640-3648. doi: 10.1021/acs.jproteome.9b00306. Epub 2019 Sep 18. PMID: 31502464 [Article]


• Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter
  Cheng L, Poulsen SB, Wu Q, Esteva-Font C, Olesen ETB, Peng L, Olde B, Leeb-Lundberg LMF, Pisitkun T, Rieg T, Dimke H, Fenton RA. J Am Soc Nephrol. 2019 Aug;30(8):1454-1470. doi: 10.1681/ASN.2018101025. Epub 2019 Jun 28. PMID: 31253651 [Article]