Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron

APSselected article for May, 2021, “Low Potassium levels linked to Water Balance Disorder More Prevalent in Women” Study by Al-Quisari, Grimm, Zaph, and Welling .

Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure

Poulsen SB, Cheng L, Penton D, Kortenoeven MLA, Matchkov VV, Loffing J, Little R, Murali SK, Fenton RA.

Kidney Int. 2021 Apr 30:S0085-2538(21)00461-0. doi: 10.1016/j.kint.2021.04.021

An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake.

Kortenoeven MLA, Cheng L, Wu Q, Fenton RA.

Am J Physiol Renal Physiol. 2021 May 1;320(5):F908-F921.

Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles.

Blijdorp CJ, Tutakhel OAZ, Hartjes TA, van den Bosch TPP, van Heugten MH, Rigalli JP, Willemsen R, Musterd-Bhaggoe UM, Barros ER, Carles-Fontana R, Carvajal CA, Arntz OJ, van de Loo FAJ, Jenster G, Clahsen-van Groningen MC, Cuevas CA, Severs D, Fenton RA, van Royen ME, Hoenderop JGJ, Bindels RJM, Hoorn EJ.

J Am Soc Nephrol. 2021 May 3;32(5):1210-1226.

Rapid Development of Vasopressin Resistance in Dietary Potassium Deficiency

Lama Al-Qusairi*, P. Richard Grimm*, Ava M. Zapf, and Paul A. Welling. at Johns Hopkins Univ Serials Dept Electronic ( on March 28, 2021.

SGLT2-inhibitors, hemodynamics, and kidney protection.

Ellison DH.
Am J Physiol Renal Physiol. 2021 Mar 22. doi: 10.1152/ajprenal.00092.2021. Online ahead of print.
PMID: 33749325 No abstract available.

Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus.

Petrillo F, Iervolino A, Angrisano T, Jelen S, Costanzo V, D’Acierno M, Cheng L, Wu Q, Guerriero I, Mazzarella MC, De Falco A, D’Angelo F, Ceccarelli M, Caraglia M, Capasso G, Fenton RA, Trepiccione F.

J Am Soc Nephrol. 2021 Mar 16:ASN.2020010031. doi: 10.1681/ASN.2020010031

Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter.

Mukherjee A, Yang CL, McCormick JA, Martz K, Sharma A, Ellison DH.
Am J Physiol Renal Physiol. 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020. Online ahead of print.
PMID: 33719576

Effect of furosemide on body composition and urinary proteins that mediate tubular sodium and sodium transport-A randomized controlled trial.

Frank Holden M, Oczachowska-Kulik AE, Fenton RA, Bech JN.

Physiol Rep. 2021 Jan;8(24):e14653. doi: 10.14814/phy2.14653.