Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.

Neumann C, Rosenbaek LL, Flygaard RK, Habeck M, Karlsen JL, Wang Y, Lindorff-Larsen K, Gad HH, Hartmann R, Lyons JA, Fenton RA,

EMBO J. 2022 Dec 1;41(23):e110169. doi: 10.15252/embj.2021110169. Epub 2022 Oct 14. PMID: 36239040; PMCID: PMC9713717.

Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.

Murillo-de-Ozores AR, Carbajal-Contreras H, Magaña-Ávila GR, Valdés R, Grajeda-Medina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin DH, Wang WH, Delpire E, Ellison DH, Gamba G, Castañeda-Bueno M.

Kidney Int. 2022 Nov;102(5):1030-1041. doi: 10.1016/j.kint.2022.06.027. Epub 2022 Jul 21. PMID: 35870644; PMCID: PMC10411384.

Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.

Petrillo F, Chernyakov D, Esteva-Font C, Poulsen SB, Edemir B, Fenton RA.

FASEB J. 2022 Nov;36(11):e22583. doi: 10.1096/fj.202200856R. PMID: 36197017.

Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.

Petrillo F, Chernyakov D, Esteva-Font C, Poulsen SB, Edemir B, Fenton RA.

FASEB J. 2022 Nov;36(11):e22583. doi: 10.1096/fj.202200856R. PMID: 36197017.

The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter NCC but is not required for a potassium-induced reduction of NCC expression.

Rosenbaek LL, Petrillo F, van Bemmelen MX, Staub O, Murali SK, Fenton RA.

Front Physiol. 2022 Sep 7;13:971251. doi: 10.3389/fphys.2022.971251. PMID: 36160843; PMCID: PMC9490057.

Detecting primary aldosteronism in Australian primary care: a prospective study.

Renata Libianto 1 2, Grant M Russell 3, Michael Stowasser 4, Stella M Gwini 5, Peta Nuttall 2, Jimmy Shen 1 2, Morag J Young 2, Peter J Fuller 1 2, Jun Yang 1 3

Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter.

Wu A, Wolley MJ, Fenton RA, Stowasser M.

Front Endocrinol (Lausanne). 2022 Aug 29;13:981317. doi: 10.3389/fendo.2022.981317. PMID: 36105401; PMCID: PMC9465297.

n Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter.

Wu A, Wolley MJ, Matthews A, Cowley D, Welling PA, Fenton RA, Stowasser M.

Kidney360. 2022 Aug 26;3(11):1909-1923. doi: 10.34067/KID.0003632022. PMID: 36514401; PMCID: PMC9717638.

Potassium homeostasis: sensors, mediators, and targets.

McDonough AA, Fenton RA

Pflugers Arch. 2022 Aug;474(8):853-867. doi: 10.1007/s00424-022-02718-3. Epub 2022 Jun 21. PMID: 35727363; PMCID: PMC10163916.

NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification. Am J Physiol Renal Physiol.

Xue J, Thomas L, Dominguez Rieg JA, Fenton RA, Rieg T.

Am J Physiol Renal Physiol. 2022 Aug 1;323(2):F141-F155. doi: 10.1152/ajprenal.00013.2022. Epub 2022 May 30. PMID: 35635321; PMCID: PMC9306792.