Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice

Maeoka Y, Ferdaus MZ, Cornelius RJ, Sharma A, Su XT, Miller LN, Robertson JA, Gurley SB, Yang CL, Ellison DH, McCormick JA.

J Am Soc Nephrol. 2022 Mar;33(3):584-600. doi: 10.1681/ASN.2021081099. Epub 2022 Jan 21.PMID: 35064051

Does the early aldosterone-induced SGK1 play a role in early Kaliuresis?

Al-Qusairi L, Basquin D, Stifanelli M, Welling PA, Staub O.

Physiol Rep. 2022 Feb;10(4):e15188. doi: 10.14814/phy2.15188. PMID: 35224872; PMCID: PMC8883148.

Pendrin-null mice develop severe hypokalemia following dietary Na+ and K+ restriction: role of ENaC.

Pham TD, Elengickal AJ, Verlander JW, Al-Qusairi L, Chen C, Abood DC, King SA, Loffing J, Welling PA, Wall SM.

Am J Physiol Renal Physiol. 2022 May 1;322(5):F486-F497. doi: 10.1152/ajprenal.00378.2021. Epub 2022 Feb 28. PMID: 35224991; PMCID: PMC8977139.

Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice.

Zapf AM, Grimm PR, Al-Qusairi L, Delpire E, Welling PA.

Front Physiol. 2022 Jan 6;12:787323. doi: 10.3389/fphys.2021.787323. PMID: 35069250; PMCID: PMC8770744.

Potassium Effects on NCC Are Attenuated during Inhibition of Cullin E3-Ubiquitin Ligases.

Murali SK, Little R, Poulsen SB, Ferdaus MZ, Ellison DH, McCormick JA, Fenton RA

Cells. 2021 Dec 29;11(1):95. doi: 10.3390/cells11010095. PMID: 35011657; PMCID: PMC8750104.

Diagnosis and treatment of primary aldosteronism

Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA. Lancet Diab Endocrinol 2021;9:876-92

Insights into Salt Handling and Blood Pressure.

Ellison DH, Welling P.N Engl J Med. 2021 Nov 18;385(21):1981-1993. doi: 10.1056/NEJMra2030212.PMID: 34788509 Review. No abstract available.

Aldosterone and Primary Aldosteronism: Star Performers in Hypertension Research

Stowasser M.Hypertension. 2021 Sep;78(3):747-750. doi: 10.1161/HYPERTENSIONAHA.121.17594. Epub 2021 Aug 11.PMID: 34379432 No abstract available.

Compensatory post-diuretic renal sodium reabsorption is not a dominant mechanism of diuretic resistance in acute heart failure

Cox ZL, Rao VS, Ivey-Miranda JB, Moreno-Villagomez J, Mahoney D, Ponikowski P, Biegus J, Turner JM, Maulion C, Bellumkonda L, Asher JL, Parise H, Wilson PF, Ellison DH, Wilcox CS, Testani JM.Eur Heart J. 2021 Sep 16:ehab620. doi: 10.1093/eurheartj/ehab620. Online ahead of print.PMID: 34529781

Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron

Nesterov V, Bertog M, Canonica J, Hummler E, Coleman R, Welling PA, Korbmacher C.Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F257-F268. doi: 10.1152/ajprenal.00139.2021. Epub 2021 Jul 12.PMID: 34251271