Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule

Wu P, Su XT, Gao ZX, Zhang DD, Duan XP, Xiao Y, Staub O, Wang WH, Lin DH. J Am Soc Nephrol. 2020 Jun;31(6):1226-1242. doi: 10.1681/ASN.2019090923.

Mg22+ restriction downregulates NCC through NEDD4-2 and prevents its activation by hypokalemia

Ferdaus MZ, Mukherjee A, Nelson JW, Blatt PJ, Miller LN, Terker AS, Staub O, Lin DH, McCormick JA. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F825-F838. doi: 10.1152/ajprenal.00216.2019. Epub 2019 Jul 31. PMID: 31364380

Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling

Canonica J, Frateschi S, Boscardin E, Ebering A, Sergi C, Jäger Y, Peyrollaz T, Mérillat AM, Maillard M, Klusonova P, Odermatt A, Koesters R, Debonneville A, Staub O, Verouti SN, Hummler E. Front Physiol. 2019 Aug 14;10:989. doi: 10.3389/fphys.2019.00989. eCollection 2019. PMID: 31474871

The serine-threonine kinase PIM3 is an aldosterone-regulated protein in the distal nephron

Spirli A, Cheval L, Debonneville A, Penton D, Ronzaud C, Maillard M, Doucet A, Loffing J, Staub O. Physiol Rep. 2019 Aug;7(15):e14177. doi: 10.14814/phy2.14177. PMID: 31397090

The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation

Rosenbaek LL, Rizzo F, Wu Q, Rojas-Vega L, Gamba G, MacAulay N, Staub O, Fenton RA. Sci Rep. 2017 Oct 11;7(1):12981. doi: 10.1038/s41598-017-12819-0. PMID: 29021560

Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion

Al-Qusairi L, Basquin D, Roy A, Rajaram RD, Maillard MP, Subramanya AR, Staub O. J Am Soc Nephrol. 2017 Aug;28(8):2431-2442. doi: 10.1681/ASN.2016070732. Epub 2017 Mar 13. PMID: 28289184

Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC

Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23. PMID: 27009335

Ubiquitylation and control of renal Na+ balance and blood pressure

Ronzaud C, Staub O. Physiology (Bethesda). 2014 Jan;29(1):16-26. doi: 10.1152/physiol.00021.2013. PMID: 24382868 Review.

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O. J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25. PMID: 23348737

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway

Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O. J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18. PMID: 21852580